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Do you have supporting medical studies?Updated 9 months ago

Although medical studies are frequently conducted for medications and drugs, they are seldom carried out for natural food supplement formulas. 

We invite you to examine the list of references for our product ingredients, and we also encourage you to undertake your own research.

Alpha Cleanse references:

1. Results from 5 studies showed a significant reduction in weight after taking Spirulina supplementation (https://pubmed.ncbi.nlm.nih.gov/31780031/)

2. Betanin as a multipath oxidative stress and inflammation modulator: a beetroot pigment with protective effects on cardiovascular disease pathogenesis (https://www.tandfonline.com/doi/full/10.1080/10408398.2020.1822277)

3. Moringa leaves are shown to be benficial in overall inflammation support. (https://pubmed.ncbi.nlm.nih.gov/29144438/)

4. Inulin consumption contributed to softer stools. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739857/

5. Spirulina supplementation contributed to significant increase in exercise performance and fat oxidation. (https://pubmed.ncbi.nlm.nih.gov/20010119/)

6. Animals and test-tube studies show that moringa can reduce fat formation. (https://pubmed.ncbi.nlm.nih.gov/30618744/)

7. Silibin, derived from milk thistle demonstrates promising effects against liver disorders. (https://pubmed.ncbi.nlm.nih.gov/27517806/)

8. Rhubarb stalk fiber. (https://pubmed.ncbi.nlm.nih.gov/9430089/)

9. Antioxidant activity in Rhubarb. (https://ifst.onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2621.2012.03174.x)

10. Positive effects of dandeliion. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553762/)

11. Nettle leaves had a protective effect on liver damage in rats. (https://pubmed.ncbi.nlm.nih.gov/22585933/)

12. Antioxidant and antimicrobial properties of Mullein leaf. (https://pubmed.ncbi.nlm.nih.gov/31456524/)

13. Hawthorn berry has shown cardiovascular protective action. (https://pubmed.ncbi.nlm.nih.gov/28608832/)

14. Prebiotics aid in gastrointestinal digestion. (https://pubmed.ncbi.nlm.nih.gov/25659062/)

15. Red clover may decrease frequency of hot flashes. (https://pubmed.ncbi.nlm.nih.gov/26471215/)

16. Burdock detoxifies the blood in terms of Traditional Chinese Medicine. (https://link.springer.com/article/10.1007/s10787-010-0062-4)

17. Schisandra provides support for menopausal symptoms. (https://pubmed.ncbi.nlm.nih.gov/27763802/)

18. Effect of eucalyptus on patients suffering from acute bronchitis. (https://pubmed.ncbi.nlm.nih.gov/24261680/)

19. Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota? (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490612/)

20. Effect of Arthrospira (Spirulina) maxima Supplementation and a Systematic Physical Exercise Program on the Body Composition and Cardiorespiratory Fitness of Overweight or Obese Subjects: A Double-Blind, Randomized, and Crossover Controlled Trial. (https://pubmed.ncbi.nlm.nih.gov/30275428/)

21. Investigating of Moringa Oleifera Role on Gut Microbiota Composition and Inflammation Associated with Obesity Following High Fat Diet Feeding. (https://pubmed.ncbi.nlm.nih.gov/30159057/)

22. The Antioxidant, Anticarcinogenic and Antimicrobial Properties of Verbascum thapsus L. (https://pubmed.ncbi.nlm.nih.gov/31456524/)

23. Gut–Liver Axis: How Do Gut Bacteria Influence the Liver? (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165386/)

24. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. (https://www.nature.com/articles/ncomms8489)

25. Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019938/)

26. Curcumin: A Review of Its’ Effects on Human Health. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/)

27. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. (https://pubmed.ncbi.nlm.nih.gov/9619120/)

Vulcan Slim references:

Weight Management Module for Perimenopausal Women: A Practical Guide for Gynecologists. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947726/)

Adipokines, adiposity, and vasomotor symptoms during the menopause transition: findings from the Study of Women’s Health Across the Nation. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759568/)

Visceral Obesity: The Link Among Inflammation, Hypertension, and Cardiovascular Disease. (https://www.ahajournals.org/doi/full/10.1161/hypertensionaha.108.110320)

The Impact of Aging on Adipose Function and Adipokine Synthesis. (https://www.frontiersin.org/articles/10.3389/fendo.2019.00137/full)

Clinical Relevance of Adipokines. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486977/)

Biochemistry, Lipolysis. (https://www.ncbi.nlm.nih.gov/books/NBK560564/)

Citrus extracts show weight management potential: Study. (https://www.nutraingredients.com/Article/2013/09/03/Citrus-extract-shows-weight-management-potential-Study)

Purple Tea and Its Extract Suppress Diet-induced Fat Accumulation in Mice and Human Subjects by Inhibiting Fat Absorption and Enhancing Hepatic Carnitine Palmitoyltransferase Expression. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502735/)

Clinical study on the combined effect of capsaicin, green tea extract and essence of chicken on body fat content in human subjects. (https://pubmed.ncbi.nlm.nih.gov/14974736/)

Effects of glucomannan supplementation on weight loss in overweight and obese adults: A systematic review and meta-analysis of randomized controlled trials. (https://www.sciencedirect.com/science/article/abs/pii/S2451847620300968?via%3Dihub)

DNF-10® Protein hydrolysate for satiety. (https://fytexia.com/dnf-10-satiety/)

Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. (https://pubmed.ncbi.nlm.nih.gov/10584049/)

Beneficial effects of Apple Cider Vinegar on weight management, Visceral Adiposity Index and lipid profile in overweight or obese subjects receiving restricted calorie diet: A randomized clinical trial. (https://www.sciencedirect.com/science/article/abs/pii/S1756464618300483)

Strategies for healthy weight loss: from vitamin C to the glycemic response. (https://pubmed.ncbi.nlm.nih.gov/15930480/)

Scientific Opinion on the substantiation of a health claim related to riboflavin (vitamin B2) and contribution to normal energy-yielding metabolism pursuant to Article 14 of Regulation (EC) No 1924/2006. (https://efsa.onlinelibrary.wiley.com/doi/abs/10.2903/j.efsa.2013.3410)

Protective effect of vitamin B6 in chromium-induced oxidative stress in liver. (https://pubmed.ncbi.nlm.nih.gov/15986493/)

Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample Mendelian randomization analysis. (https://pubmed.ncbi.nlm.nih.gov/27901035/)

Vitamin C and oxidative stress in the seminiferous epithelium. Pubmed, 2011.

Strategies for Healthy Weight Loss: From Vitamin C to the Glycemic Response. Journal of the American College of Nutrition, 2005.

Vitamin B6 level is associated with symptoms of depression. Pubmed, 2004.

Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Bioscience, Biotechnology, and Biochemistry, 2009.

Glucomannan and obesity: a critical review. Alternative Therapies in Health and Medicine, 2005.

Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. The American Journal of Clinical Nutrition, 1999.

Metabolic effects of spices, teas, and caffeine. Physiology & Behavior, 2006.

Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE). Phytomedicine, 2008.

Effects of a Standardized Purple Tea Extract on Diet-Induced Thermogenesis and Fat Oxidation. Nutrients, 2020.

Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. The American Journal of Clinical Nutrition, 2009.

Vitamin B12 increases energy expenditure and reduces RQ in non-anorectic and non-bulimic vegetarians. European Journal of Clinical Nutrition, 1994.

A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial. BMC Complementary and Alternative Medicine, 2017.

Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Biosci Biotechnol Biochem, 2007.

Low Vitamin B12 and Lipid Metabolism: Evidence from Pre-Clinical and Clinical Studies. Nutrients, 2020.

Yeast hydrolysate reduces body fat of dietary obese rats. Phytother Res. 2004.

Lunite References:

Trusted Scientific Sources

Auld, F., Maschauer, E. L., Morrison, I., Skene, D. J., & Riha, R. L. (2017). Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Medicine Reviews, 34, 10-22.

Zarrinpar, A., Chaix, A., Yooseph, S., & Panda, S. (2014). Diet and feeding pattern affect the diurnal dynamics of the gut microbiome. PLOS ONE, 9(12), e114205.

Kalman, D. S., Feldman, S., Feldman, R., Schwartz, H. I., Krieger, D. R., & Garrison, R. (2008). Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutrition Journal, 7(1), 11.

Sarrica, A., Kirika, N., Romeo, M., Salmona, M., & Diomede, L. (2018). Safety and Toxicology of Magnolol and Honokiol. Frontiers in Neurology, 9, 746.

Schuette, S. A., Lashner, B. A., & Janghorbani, M. (1994). Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. Journal of Parenteral and Enteral Nutrition, 18(5), 430-435.

Grober, U., Schmidt, J., & Kisters, K. (2015). Magnesium in Prevention and Therapy. Nutrients, 7(9), 8199–8226.

Nielsen, F. H., Johnson, L. K., & Zeng, H. (2010). Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnesium Research, 23(4), 158-168.

Wolfson, P., & Hoffmann, D. L. (2003). An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. J Altern Complement Med, 9(1), 75-83.

Brock, C., Whitehouse, J., Tewfik, I., & Towell, T. (2014). American Skullcap (Scutellaria lateriflora): A Randomised, Double‐Blind Placebo‐Controlled Crossover Study of its Effects on Mood in Healthy Volunteers. Phytotherapy Research, 28(5), 692-698.

Gyllenhaal, C., Merritt, S. L., Peterson, S. D., Block, K. I., & Gochenour, T. (2000). Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep Medicine Reviews, 4(2), 229-251


A meta-analysis found that melatonin decreased sleep onset latency (the time it takes to fall asleep) in various sleep disorders. https://pubmed.ncbi.nlm.nih.gov/28648359/


Research has shown that melatonin improves sleep efficiency and increases total sleep duration. https://pubmed.ncbi.nlm.nih.gov/31368204/


Studies have found melatonin to be effective in reducing jet lag symptoms. https://pubmed.ncbi.nlm.nih.gov/15272110/


A study on older adults found that magnesium supplementation improved sleep quality. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/


Magnesium plays a role in neurotransmitter function and muscle relaxation, contributing to restful sleep. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452159/


Magnesium is a co-factor in multiple biochemical reactions involved in energy metabolism. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549665/


Studies have shown that Magnolia Bark has anxiolytic effects, reducing stress and anxiety. https://pubmed.ncbi.nlm.nih.gov/18541130/


The anxiolytic effects of Magnolia Bark contribute to better sleep quality. https://pubmed.ncbi.nlm.nih.gov/18541130/


Studies have found that Skullcap has anxiolytic effects, helping to relieve anxiety and stress. https://pubmed.ncbi.nlm.nih.gov/12652886/


Some studies suggest that Skullcap has mood-enhancing properties. https://pubmed.ncbi.nlm.nih.gov/23878109/


Due to its calming effects, Skullcap has been used traditionally to aid sleep. https://pubmed.ncbi.nlm.nih.gov/10838653/

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